Since you're not smart enough to do actual research I'll save you the trouble. I've been looking into Selenium recently since I've noticed much of my healthy foods contain too much of it and I'm probably going over the 400 mcg per day limit.
Selenium toxicity
Selenium toxicity, also known as selenosis, can occur when excessive amounts of selenium are ingested over time or in a single large dose. Here are some key points about selenium toxicity:
Symptoms: Common symptoms of selenium toxicity include nausea, vomiting, hair loss, nail discoloration or brittleness, joint pain, fatigue, irritability, and a garlic odor in the breath.
Diagnosis: Selenium toxicity is typically diagnosed based on clinical symptoms, as there are no specific biochemical or preclinical parameters for diagnosis.
Causes: Selenium toxicity can be caused by accidental over-supplementation with dietary supplements, contaminated water sources, or prolonged consumption of selenium-rich forages in animals.
Recommended Intake: The recommended dietary allowance for selenium varies by age, with adults and pregnant women requiring 400 µg per day.
Toxic Levels: Acute selenium poisoning can occur at doses much higher than the recommended intake, such as the case of a dietary supplement containing 200 times the labeled concentration of selenium, leading to symptoms in 201 cases across 10 states.
Mechanism: Selenium toxicity can disrupt the balance between reactive oxygen species (ROS) production and antioxidant capacity, leading to oxidative damage and impairing critical physiological functions.
Prevention: Regular testing of soil and forages in high-selenium areas can help prevent chronic selenium poisoning in livestock and horses.
Treatment: Treatment for selenium toxicity depends on the severity and type of poisoning. For chronic cases, supportive care and removal of the selenium source are recommended. Acute poisoning is often fatal, with limited treatment options.
Geographical Distribution: Selenium is unevenly distributed in the environment, with certain regions having high concentrations that can lead to toxicity in both humans and animals.
Sources: Selenium can be found in various forms, including elemental selenium, selenite, selenate, selenide, selenomethionine, and selenocysteine, each with different levels of toxicity and absorption in the body.